Craig L. Franklin
Associate Professor
DVM, University of Missouri-Columbia
MS, University of Missouri-Columbia
PhD, University of Missouri-Columbia
Diplomate, American College of Laboratory Animal Medicine
Director of Graduate Studies, Comparative Medicine Program
Research emphasis: Dr. Franklin has two primary research foci:
1) Pathogenesis of chronic intestinal mucosal inflammation (i.e. Crohn’s
disease, collagenous colitis, irritable bowel syndrome). This includes studies
of the role of gonadal sex hormones in modulating mucosal inflammation using
a rodent Helicobacter hepaticus infection model. 2) Characterization and study
of mutant rodent animal models for human disease. The latter involves several
collaborative projects including characterization of a novel kidney disease
(glomerulopathy) of oim/oim mice, studies on the immunopathogenesis of multiple
sclerosis using mouse models and the phenotypic characterization of genetically-engineered
mutant mouse and rat models through the MU Mutant Mouse and Rat Resource Centers.
Teaching: Veterinary Immunology, Rodent Biology, Comparative Pathology, Laboratory Animal Medicine
Selected publications:
Livingston, R.S., M.H. Myles, B.A. Livingston, J.M. Criley and C.L. Franklin. Sex influence on chronic intestinal inflammation in Helicobacter hepaticus-infected A/JCr mice. Comp. Med. (in press)
Myles, M.H., R.S. Livingston, and C.L. Franklin. Pathogenicity of Helicobacter rodentium in A/JCr and SCID Mice. Comp Med (in press)
Myles, M.H., R.S. Livingston, B.A. Livingston, J.M. Criley, and C.L. Franklin. cDNA Array Analysis of Altered Gene Expression in Ceca of Helicobacter hepaticus Infected A/JCr Mice Before and After Development of Typhlitis. Infect Immun. 71:3885-3893, 2003.
Phillips, C.L., B.J. Pfeiffer, A.M. Luger, and C.L. Franklin. Novel collagen glomerulopathy in a homotrimeric collagen mouse (oim). Kid. Internat. 62: 383-391, 2002.
Kendall, L.V., L.K. Riley, R.R. Hook, Jr., C.L. Besch-Williford, and C.L. Franklin. Characterization of Lymphocyte Subsets in the Bronchiolar Lymph Nodes of CAR Bacillus Infected BALB/c Mice. Comp. Med.52:322-327, 2002
Franklin, C.L., P.L. Gorelick, L.K. Riley, F.E. Dewhirst, R.S. Livingston, J.M. Ward, C.S. Beckwith, and J G. Fox. Helicobacter typhlonius sp. nov., a novel murine urease-negative helicobacter. J. Clin. Microbiol. 39:3920-3870, 2001
Kendall, L.V., L.K. Riley, R.R. Hook, Jr., C.L. Besch-Williford, and C.L. Franklin. Differential Interleukin-10 and Gamma-Interferon mRNA Expression in Lungs of CAR bacillus-infected mice. Infect Immun 69:3697-3702, 2001.
Kendall, L.V., L.K. Riley, R.R. Hook, Jr., C.L. Besch-Williford, and C.L. Franklin. Antibody and cytokine responses to the Cilia-Associated Respiratory (CAR) bacillus in BALB/c and C57BL/6 mice. Infect. Immun. 68 4961-4967, 2000.
Simmons, J.H., L.K. Riley, C.L. Besch-Williford, and C.L. Franklin. Helicobacter mesocricetorum sp. nov., a novel helicobacter isolated form the feces of Syrian hamsters J. Clin, Microbiol. 38:1811-1817, 2000
Livingston, R.S., L.K. Riley, R.R. Hook, Jr., C.L. Besch-Williford, and C.L. Franklin. Cloning and expression of an immunodominant membrane-associated protein of Helicobacter hepaticus for use in enzyme-linked immunosorbent assay. Clin. Diag. Lab. Immunol. 6:745-750, 1999.
Franklin C.L., L.K. Riley, R.S. Livingston, C.S. Beckwith, C.L. Besch-Williford, and R.R. Hook, Jr. Enterohepatic lesions in SCID mice infected with Helicobacter bilis. Lab. Anim. Sci. 48:334-339, 1998
Franklin, C.L., C.S. Beckwith,
R.C. Livingston, S.V. Gibson, L.K. Riley, C.L. Besch-Williford, and R.R. Hook,
Jr. Isolation of a novel Helicobacter species, Helicobacter cholecystus sp.
nov., from the bile of hamsters with cholangiofibrosis and centrilobular pancreatitis.
J. Clin. Microbiol. 34:2952-2958, 1996.