D. Mark Estes
Professor
PhD, Texas A&M University
Research emphasis: Dr. Estes' research focuses on studies of bovine B cell development and differentiation, cell trafficking and inflammation. Related investigations led to identification of a novel peptide which enhances IgA responses.
Major achievements include receiving a patent for functional reconstitution of the SCID mouse with a bovine hematolymphoid system, related research projects have been funded by Pfizer Inc. to extend development of the SCID-bo mouse.
New research administrative duties
included the directorship of PPAID, a federally funded research initiative.
.
Teaching: Immunology
Selected publications:
Smith RA, Kreeger JM, Alvarez AJ, Goin JC, Davis WC, Whipple DL, Estes DM. Role of CD8+ and WC-1+ gamma/delta T cells in resistance to Mycobacterium bovis infection in the SCID-bo mouse. J Leuk Biol 65:28-34.
Brown WC, McElwain TF, Palmer GH, Chantler SE, Estes DM. Bovine CD4+ T-lymphocyte clones specific for rhoptry associated protein-1 (RAP-1) of Babesia bigemina provide cognate help for IgG1 and IgG2 synthesis. Infect Immun 67:155-164.
Von Beust BR, Brown WC, Estes DM, Zarlenga DS, McElwain TF, Palmer GH. Development and in vitro characterization of recombinant vaccinia viruses expressing BLV gp51 in combination with bovine IL4 or IL12. Vaccine 17:384-395.
Tuo W, Estes DM, Brown WC. Comparative effects of IL-12 and IL-4 on cytokine responses by antigen-stimulated memory CD4+ T cells of cattle: IL-12 enhances IFN-production, whereas IL-4 has marginal effects on cytokine expression. J Interferon Cytokine Res 19:741-749.
Trigona WL, Hirano A, Brown WC, Estes DM. Biology of interleukin-13 in cattle. J Interferon Cytokine Res 19:1317-1324.
Haas, K.M. and D.M. Estes. 2000. Activation of bovine B cells via sIgM crosslinking or CD40 ligation results in different B cell phenotypes: implications for development of B-1-like B cells in cattle. Immunology 99:272-278.